|
|
|
|
|
| Sá,Rita de Cássia da Silveira e; Leite,Magda Narciso; Peters,Vera Maria; Guerra,Martha de Oliveira; Almeida,Reinaldo Nóbrega de. |
| This work makes an assessment of the dominant lethality of Mikania glomerata in male Wistar rats. Adult male received 1 mL of M. glomerata hydroalcoholic extract at a dose level of 3.3 g/kg body weight for 52 days and were mated with untreated females for seven weeks (group 1) or one week prior to the beginning of treatment and on the week following the end of treatment (group 2). The parameters analyzed were: number of implanted embryos, resorptions and corpora lutea; mating, gestation, preimplantation loss, implantation and resorption indexes (group 1); number of offspring and weaning animals (group 2). The administration of M. glomerata did not show any impairment of fertility and no significant difference in the parameters analyzed, suggesting an... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Mikania glomerata; Mutagenicity; Wistar rat. |
| Ano: 2006 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132006000500009 |
| |
|
|
| Maganha,Juliana; Rocha,Evelise de Souza; Brandão,Marcos Antônio Fernandes; Peters,Vera Maria; Guerra,Martha de Oliveira. |
| Lapachol, a naphthoquinone extracted from plants of the genus Tabebuia (family Bignoneaceae), showed multiple therapeutic activities. Pregnant Wistar rats were treated with Lapachol from the 1st to the 4th (pre-implantation period) and from 5th to 7th (implantation period) post insemination day (PID). Mothers were sacrificed on the 5th or on the15th PID. Number of corpora lutea, preimplantation embryo, blastocysts, live and dead fetuses and resorptions were counted. There were no signs of maternal toxicity. The number and the morphology of embryos, during oviduct development (pre-implantation period), did not seem to be affected by this drug, but during the implantation period, lapachol was toxic causing the death of embryos and intrauterine growth... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Lapachol; Embryo development; Rat; Reproductive toxicity. |
| Ano: 2006 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132006000700010 |
| |
|
| |
|
|
|
